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Immunodeficiency

Immunodeficiency Online Doctors Consultation

19 questions

Experience the Precision of Evidence-Based Medicine in Managing Immunodeficiency Disorders Through Our Online Consultations Discover science-backed solutions for immune system-related concerns with our online consultations. Our platform connects you with experienced medical professionals specializing in evidence-based treatments for immunodeficiency disorders, providing timely and accurate guidance. We address conditions such as primary immunodeficiency (PID), secondary immunodeficiency, recurrent infections, autoimmune diseases, HIV/AIDS management, chronic fatigue syndrome, and other immune-related issues. Through confidential and accessible consultations, our doctors help identify the root causes of immune dysfunction and recommend personalized treatment plans grounded in the latest clinical research. Early diagnosis and medical intervention can prevent complications, strengthen your immune system, and improve your quality of life. Whether you’re experiencing frequent infections, prolonged illness, fatigue, or other symptoms, our team is ready to provide expert support and tailored solutions. Our evidence-based approach ensures accurate diagnoses and effective treatments, with options for both free and paid consultations. Without requiring site registration, our licensed practitioners deliver professional and anonymous advice, all from the comfort of your home. Take the first step toward improving your immune health—consult an evidence-based medicine specialist online today!

Questions about Immunodeficiency

what is the function of lymph

31 days ago
1 answers

I recently heard about the lymphatic system and how it plays a role in immunity, but I don’t fully understand it. What is the function of lymph, and why is it so important for our health? I always thought blood was responsible for carrying nutrients and removing waste, so what does lymph do that’s different? From what I read, the function of lymph is to help fight infections and remove toxins from the body. But how exactly does it do that? Does it work like blood circulation, or does it move differently? I also saw that the lymphatic system doesn’t have a pump like the heart—so how does lymph actually flow through the body? I also want to know if problems with the lymphatic system can cause serious health issues. If someone has swollen lymph nodes, does that mean their immune system is overactive, or could it be a sign of infection or even cancer? When should someone worry about swollen lymph nodes? Another thing I’m wondering is how to keep the lymphatic system healthy. Are there specific foods, exercises, or habits that help lymph flow better? I read that massages and staying hydrated can help, but do they actually make a difference? For those who have had issues with lymphatic health, what symptoms did you experience? Did treatments like lymphatic drainage or lifestyle changes help improve your condition? I just want to understand more about the function of lymph and how to keep it working properly.


Dr. Evgeny Arsentev
30 days ago
The lymphatic system plays a crucial role in immunity and waste removal, but its function is slightly different from blood circulation. Lymph is a clear fluid that carries immune cells, particularly lymphocytes, which help fight infections. It also collects waste products, toxins, and excess fluids from tissues to be filtered and removed by the lymph nodes. Unlike blood, lymph doesn’t circulate through a pump like the heart. Instead, it moves through the lymphatic vessels aided by muscle contractions, breathing, and body movements. Swollen lymph nodes can be a sign of an infection, inflammation, or, in rarer cases, a more serious condition like cancer. If the swelling is persistent or painful, it’s best to see a doctor to determine the cause. To keep your lymphatic system healthy, staying hydrated, regular exercise, and practices like deep breathing or gentle massages can help promote lymph flow. There’s also some evidence suggesting that a healthy diet rich in antioxidants and anti-inflammatory foods supports immune function.
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What is Lymph?

32 days ago
1 answers

I recently came across the term Lymph, and I realized I don’t fully understand what it is. I know it has something to do with the immune system, but what exactly is Lymph, and why is it important?? From what I read, Lymph is a clear fluid that travels through the lymphatic system, carrying white blood cells and waste materials. But how does it actually work? Does Lymph help fight infections, or does it just transport immune cells?? I also saw that the Lymphatic System includes lymph nodes, lymph vessels, and the spleen. But what role do lymph nodes play? I’ve heard that swollen lymph nodes can mean an infection—does that mean the immune system is working harder?? One thing I’m really curious about—what happens if the Lymphatic System doesn’t work properly? I read that conditions like lymphedema can cause fluid buildup, but can problems with Lymph also weaken the immune system?? For those who have studied the Lymphatic System, what’s the most interesting thing you’ve learned? And are there ways to naturally boost Lymphatic flow to improve immune function??


Dr. Evgeny Arsentev
30 days ago
Lymph is a clear fluid that flows through your lymphatic system, carrying white blood cells, waste materials, and other substances throughout the body. Its main function is to support the immune system by transporting immune cells that fight infections. It also helps remove toxins and waste from tissues. Lymph nodes, part of the lymphatic system, act as filters. They trap harmful substances, such as bacteria or viruses, and help your body fight infections. When the body detects an infection, lymph nodes can become swollen, indicating that the immune system is working to fight off the invader. If the lymphatic system doesn’t work properly, conditions like lymphedema (fluid buildup) can occur. This can affect immune function as well because the lymphatic system plays an important role in immune surveillance. To support lymphatic flow, gentle exercise, staying hydrated, and maintaining a healthy diet can help.
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How to know I have hiv or not

12 days ago
0 answers

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NK Cells

19 days ago
1 answers

A few months ago, I started getting sick way more often than usual. I’ve always had a pretty strong immune system, but lately, I’ve been catching every little cold, and it takes me forever to recover. I had a lingering sinus infection that lasted almost six weeks, and then right after that, I got the flu, even though I got my flu shot. My doctor ran some tests, and they mentioned something about my NK cells being low. I had no idea what that even meant, but they said NK cells are important for fighting infections and possibly even cancer. I started looking into it, and now I’m wondering if this is why I’ve been getting sick so much. If my NK cells are low, does that mean my immune system is permanently weak, or can this be fixed? My doctor mentioned something about chronic immune dysfunction, but I don’t have any diagnosed conditions like HIV or an autoimmune disease (at least not that I know of). Could stress or diet affect NK cells, or is this more of a genetic thing? I also read that NK cells play a role in detecting abnormal cells, which freaked me out a bit. Does having low NK cells increase my risk of something serious, like cancer? I’ve always been generally healthy, but now I’m wondering if I should be doing something specific to boost my immune system. Are there treatments or supplements that actually help increase NK cells, or is this something that just has to be monitored? Is there a way to know if this is temporary or if I should be worried about long-term immune problems? I just don’t want to keep getting sick all the time, and I definitely don’t want to ignore something that could turn into a bigger issue down the road.


Dr. Evgeny Arsentev
18 days ago
It sounds like you're experiencing a concerning shift in your immune health, and it's understandable to be worried, especially with your previous history of having a strong immune system. The low level of natural killer (NK) cells your doctor mentioned can indeed play a significant role in your immune response to infections and potentially in cancer surveillance. First, it is essential to clarify that having low NK cells does not necessarily mean your immune system is permanently weak or that you're destined to have chronic immune dysfunction. NK cell levels can fluctuate due to various factors, including stress, diet, infections, and even the body’s inflammatory state. Chronic stress can indeed lead to immune dysregulation, and a poor diet lacking in essential nutrients might impede your immune response. Ensuring you have a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and essential fatty acids can support immune function more broadly. If your NK cells are low, it would be prudent to follow up with your healthcare provider for more information about the root causes and the implications for your health. They may refer you to an immunologist or suggest further tests. Identifying the reason for the low NK cell count is important—it could be transient and related to your recent illnesses or it could indicate a more significant underlying issue. Regarding your question about whether low NK cells increase your risk of serious conditions like cancer, while NK cells do play a role in tumor surveillance, low NK cell levels alone do not directly equate to an increased risk of cancer. The overall health of your immune system and the function of other immune cells also contribute to your cancer risk. To manage your symptoms and improve your immune health while working with your healthcare team, consider the following actionable steps: 1. **Diet**: Focus on a nutrient-rich diet. Foods high in vitamins C and E, zinc, and omega-3 fatty acids may benefit immune function. Include fruits like oranges and berries, vegetables like spinach and bell peppers, and foods like nuts and fatty fish. 2. **Exercise**: Regular, moderate exercise can enhance immune function. Aim for at least 150 minutes of moderate aerobic activity weekly, as tolerated. 3. **Sleep**: Ensure you are getting adequate sleep, as insufficient sleep can negatively affect immune response. 4. **Stress Management**: Incorporate stress-reducing activities such as mindfulness, meditation, or yoga, as chronic stress can adversely affect your immune system. 5. **Hydration**: Stay well-hydrated to support overall health and immune function. 6. **Follow-up Care**: Given your symptoms and the findings about your NK cells, it is crucial to schedule regular follow-up appointments with your healthcare provider to monitor your immune function and discuss any additional tests or treatments that may be necessary. While there are some supplements that are believed to potentially support immune function, including zinc and vitamin D, you should consult your healthcare provider before starting any new supplements to ensure they are appropriate for you. In summary, while low NK cells can affect your immune response, it is possible to improve your overall immune health through lifestyle changes, and close monitoring and follow-up with your healthcare provider are essential. Pay attention to symptoms, and do not hesitate to seek immediate medical attention if you experience recurrent or severe infections. Be proactive about your health, and keep an open dialogue with your healthcare team for the best possible outcomes.
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Antigen

26 days ago
1 answers

I recently had a blood test, and one of the results mentioned something about an antigen test. I don’t fully understand what antigen means—does it always relate to infections, or can it be something else? From what I’ve read, antigens are substances that trigger an immune response, but are they always bad? Are there good antigens, or does the body always try to fight them off? I also noticed that COVID-19 tests often look for antigens. How does an antigen test work compared to an antibody test? Does a positive antigen test always mean someone is sick, or could it just mean they were exposed to a virus before? Another thing I’m confused about is how vaccines use antigens. If vaccines introduce an antigen to the body, does that mean we’re being exposed to a small part of the virus? How does the immune system remember how to fight it later? Are there different types of antigens in the body naturally, or do they always come from external sources like viruses and bacteria? And do all antigens cause symptoms, or can we have some in our body without even knowing? I just want to understand antigens better—what they do, how they work, and why doctors test for them.


Dr. Evgeny Arsentev
25 days ago
Antigens are indeed substances that trigger an immune response, and they can come from various sources including pathogens like viruses and bacteria, but also from non-infectious sources such as allergens or even cells from other individuals (like during organ transplants). Antigens are not inherently bad; instead, they are recognized by the immune system to help it identify and fight infections or other foreign substances. In terms of the types of antigens, those you encounter can be broadly categorized: 1. Pathogen-specific antigens: These are usually associated with infections and can elicit a strong immune response, such as viral or bacterial antigens. 2. Allergens: These are substances that can provoke an exaggerated immune response in susceptible individuals, like pollen or certain foods. 3. Self-antigens: These are typically present in the body and are normally tolerated but can sometimes cause autoimmune diseases if the immune system mistakenly identifies them as foreign. About COVID-19 testing, antigen tests and antibody tests serve different purposes: - Antigen tests: These detect specific proteins from the virus that causes COVID-19. A positive result generally indicates an active infection, but it does not always correlate with how infectious a person may be. These tests are primarily used to diagnose current infections. - Antibody tests: These measure the immune response in the form of antibodies that develop after exposure to the virus. A positive result from an antibody test suggests previous exposure to the virus, not an active infection. Vaccines introduce antigens into the body, but they typically use a harmless part of the virus (like a protein or specific genetic material) that trains the immune system to recognize it without causing the disease. This process allows the immune system to "remember" the antigen through memory cells, so if the body encounters the virus again, it can mount a faster and more effective response. Antigens can be found in the body naturally, especially self-antigens, which are normally not harmful as the immune system has learned to tolerate them. Not all antigens cause symptoms; for example, your body can have benign antigens without triggering any noticeable immune reaction or symptoms. Doctors test for antigens to aid in diagnosing infections or understanding immune responses. Understanding your immune system's interaction with these substances can provide insights into existing infections, exposure history, and overall immune health. If you have specific concerns or findings in your blood tests, discussing them with your healthcare provider will give you tailored information and guidance based on your medical history.
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eosinophils high

31 days ago
1 answers

I just got my blood test results, and my doctor pointed out that my eosinophils are high. I had no idea what eosinophils were before this, but after doing some research, I learned that they’re a type of white blood cell involved in allergic reactions and fighting infections. Now I’m wondering—what does it really mean if eosinophils are high? I don’t have any major allergies that I know of, but I do have occasional sneezing and itchy eyes, especially during certain seasons. Could mild allergies be enough to raise my eosinophils, or does a high count usually mean something more serious? I also read that parasites can cause high eosinophils. I haven’t traveled anywhere exotic, but could something like a stomach infection or gut issues cause an increase? Would I need more tests to check for parasites, or would my doctor already know based on my bloodwork? Another thing I’m wondering about is asthma. I sometimes have a tight feeling in my chest, especially after exercising. Could high eosinophils be a sign of eosinophilic asthma, and how would I know if I have it? My report didn’t say exactly how high my eosinophils are—just that they were above the normal range. How high is too high? At what level should I be concerned? And if my eosinophils are high, what can I do about it? Do they go back to normal on their own, or do I need treatment? Also, should I avoid anything that might make them go even higher, like certain foods or medications?


Dr. Evgeny Arsentev
30 days ago
Eosinophils are a type of white blood cell involved in allergic reactions, fighting infections, and responding to parasites. A high eosinophil count can sometimes indicate an allergic reaction, even mild ones like seasonal allergies. It’s also linked to conditions such as asthma, parasitic infections, or autoimmune diseases. From what you've described, your occasional sneezing and itchy eyes could be enough to cause a mild increase in eosinophils, especially if you’re sensitive to certain allergens. As for parasites, while they can raise eosinophil levels, the fact that you haven’t traveled to areas where these are common makes this less likely. If your doctor hasn’t suggested further tests, they likely didn’t see any immediate concern for a parasitic infection based on your bloodwork. Regarding asthma, eosinophilic asthma is one possibility, especially with the chest tightness you experience after exercise. It might be worth discussing this with your doctor to see if further tests like spirometry or allergy tests are needed. In terms of how high your eosinophils are, it's important to follow up with your doctor, who can help interpret the results and decide if more testing or treatment is necessary. Eosinophil levels that are mildly elevated may return to normal once the underlying cause is treated, but your doctor will guide you on the best next steps. Avoiding triggers like allergens or irritants that worsen your symptoms can be helpful.
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Sputnik V Vaccine Side Effects

25 days ago
1 answers

I recently came across the Sputnik V vaccine, and I wanted to learn more about its effectiveness and possible side effects. I know it was developed in Russia to protect against COVID-19, but I’m curious about how it compares to other vaccines like Pfizer, Moderna, or AstraZeneca. From what I’ve read, the Sputnik V vaccine uses a two-dose adenovirus vector approach, similar to some other COVID-19 vaccines. But how does this technology work, and does it provide strong immunity? How long does it take to develop protection after getting the second dose? One thing I’m really curious about is the potential Sputnik V vaccine side effects. I read that common side effects include fever, fatigue, muscle pain, and headache. But are these reactions mild and temporary, or can some people experience more severe side effects? I also want to understand whether the Sputnik V vaccine has any rare but serious risks. I’ve heard that some COVID-19 vaccines have been linked to blood clotting issues—does Sputnik V have any similar concerns? Are there certain groups of people who should avoid this vaccine? Another thing I’m wondering about is how Sputnik V vaccine side effects compare to other vaccines. Is it generally considered safer, or does it have a higher rate of adverse reactions? How do medical professionals monitor and manage any serious side effects? If anyone has received the Sputnik V vaccine, I’d love to hear about your experience. Did you experience any side effects, and how long did they last? Also, has it been effective in preventing COVID-19 and its variants?


Dr. Evgeny Arsentev
24 days ago
The Sputnik V vaccine is indeed a two-dose adenoviral vector vaccine developed in Russia to combat COVID-19. It uses a modified version of a common cold virus (adenovirus) to deliver a piece of the SARS-CoV-2 virus's genetic material, which in turn stimulates an immune response. Specifically, the vaccine employs two different adenoviral vectors (Ad26 and Ad5) for its two doses, which is distinct from some other vaccines. Regarding effectiveness, clinical trials have shown that Sputnik V has an efficacy rate of around 91-92% in preventing symptomatic COVID-19, which places it in a similar range to the Pfizer and Moderna vaccines. It can take about two weeks after the second dose to develop strong immunity, which aligns with the typical timeline for other vaccines. Common side effects from the Sputnik V vaccine include mild to moderate reactions like fever, fatigue, muscle pain, and headache. These reactions are generally temporary, lasting a few days at most. However, while severe side effects are rare, they can occur. These might include allergic reactions, although the rates of such reactions appear to be low compared to other vaccines. Regarding blood clotting issues, as of the latest data, there have been no significant reports linking the Sputnik V vaccine to thromboembolic events like those associated with some adenoviral vector vaccines (e.g., AstraZeneca and Johnson & Johnson). However, it's crucial to consult with a healthcare professional about individual medical history, as certain groups, such as pregnant or breastfeeding individuals and those with a history of severe allergic reactions, may have specific considerations. In terms of monitoring, health authorities have processes in place to track adverse reactions to vaccines. For any serious side effects, individuals are encouraged to report them to healthcare providers or through specific monitoring systems. Vaccination sites often provide direction on how to report these effects. Comparing Sputnik V to other vaccines, the incidence of mild side effects appears to be comparable to those of Pfizer and Moderna. However, each vaccine can have unique reactions, and individual experiences can vary widely. If you are considering receiving the Sputnik V vaccine, it is important to discuss it with your healthcare provider, who can give personalized advice based on your medical history, the current COVID-19 situation, and guidance from health authorities.
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what are monoclonal antibodies

31 days ago
1 answers

I’ve been hearing a lot about monoclonal antibody treatments, especially during the pandemic, but I still don’t fully understand what they are. What are monoclonal antibodies, and how do they actually work in the body? Are they the same as vaccines, or do they work differently? I read that monoclonal antibodies are used to treat certain diseases like COVID-19, cancer, and autoimmune disorders. But how do they target specific illnesses? Do they work like natural antibodies that our body makes, or are they completely synthetic? Also, if monoclonal antibodies can help fight infections, why don’t we use them for things like the flu or the common cold? Are they only made for serious conditions, or could they be developed for everyday illnesses too? I saw that some people receive monoclonal antibodies through IV infusions. Does that mean they only work for people who are already sick? Can they also be used to prevent disease, or are they strictly for treatment? Another thing I’m wondering about is side effects. Are monoclonal antibodies safer than traditional medications, or do they have serious risks? I read that some people can have allergic reactions—how common is that? If someone receives monoclonal antibodies, does the protection last long-term, or does it wear off quickly? Do they boost the immune system, or do they just act as temporary protection? For those who have taken monoclonal antibodies for an illness, did they actually help you recover faster? Were there any side effects? I’m curious if they’re really as effective as people say.


Dr. Evgeny Arsentev
30 days ago
Monoclonal antibodies are laboratory-made molecules designed to mimic the natural antibodies your body produces to fight off infections and diseases. They target specific antigens, which are molecules on the surface of harmful pathogens, such as viruses, or cells, such as cancer cells. Unlike vaccines, which stimulate your immune system to produce its own antibodies, monoclonal antibodies are pre-made and administered directly to help fight disease. They’re not typically used for everyday illnesses like the flu or common cold because those viruses often mutate quickly, making it harder to create effective monoclonal antibodies for them. Monoclonal antibodies are more commonly used for serious conditions, like cancer, autoimmune diseases, and COVID-19, where they can be highly targeted and effective. Monoclonal antibodies are often administered through IV infusions, and while they are primarily used for treatment, some can also be used for prevention, especially in high-risk individuals, like those with compromised immune systems. As for side effects, they are generally well-tolerated but can cause allergic reactions in some people. These reactions are rare but can happen. They may also have temporary effects, so the protection provided by monoclonal antibodies doesn’t last as long as a vaccine, and further treatments may be needed over time.
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Antigen and Antibody

26 days ago
1 answers

Recently, I had a blood test that checked for certain antigens and antibodies, and I realized I don’t fully understand the difference between them. I know they’re both part of the immune system, but now I’m trying to figure out how they interact and why they are important. From what I read, an antigen is a substance that triggers an immune response, while an antibody is a protein produced by the immune system to fight off infections. But how do antigens enter the body? Are they always from viruses and bacteria, or can they come from other sources like vaccines or even foods? I also saw that antigen and antibody tests are commonly used to diagnose infections. How do doctors use these tests to tell whether someone has a current infection versus a past one? Do antibody tests always mean a person is immune, or can antibodies fade over time? Another thing I’m wondering about is how vaccines work with antigens and antibodies. I read that vaccines introduce a harmless antigen to stimulate antibody production, but how long do vaccine-generated antibodies last? Do some vaccines provide lifelong immunity while others require booster shots? If someone has an autoimmune disease, does that mean their body mistakenly attacks its own antigens? How do doctors differentiate between a normal immune response and an overactive immune system that leads to autoimmune conditions? I just want to understand how antigens and antibodies work together in the immune system. Are there ways to naturally boost antibody production, or does the body regulate it on its own?


Dr. Evgeny Arsentev
25 days ago
Your understanding of antigens and antibodies as components of the immune system is a great start, and it's important to delve deeper into how they function and interact. Here's a structured overview addressing your questions about antigens, antibodies, their roles in medical testing, vaccination, autoimmune diseases, and more. Antigens are indeed substances that provoke an immune response. They can be derived from various sources, including: 1. Pathogens: Most commonly, antigens come from bacteria, viruses, and parasites. 2. Vaccines: Vaccines contain attenuated or inactivated pathogens or parts of pathogens (like proteins) designed to stimulate an immune response without causing disease. 3. Other Sources: Antigens can also be found in toxins, allergens (like pollen or pet dander), and even certain food proteins. Food sensitivities can lead to immune reactions, but they are typically not infectious in nature. Antibody testing can help indicate whether someone has a current or past infection. Here’s how: - IgM antibodies: These are generally produced first in response to an infection, indicating a recent infection. - IgG antibodies: These usually develop later and may indicate a past infection. High levels might suggest previous exposure or vaccination. It's important to note that the presence of antibodies doesn’t always guarantee immunity. Antibodies can decline over time, and in some cases, individuals may not achieve full immunity after infection or vaccination. Regarding vaccines, the duration of antibody protection varies: - Some vaccines, like those for measles or polio, can provide lifelong immunity after a complete series. - Others, such as the flu vaccine, require annual boosters due to changes in the virus and waning immunity. In autoimmune diseases, the immune system mistakenly produces antibodies against the body's own tissues. Differentiating between a normal immune response and an autoimmune reaction often involves: - Symptoms: Autoimmune diseases have specific symptom patterns (like joint pain in rheumatoid arthritis or organ dysfunction in lupus). - Blood tests: Certain autoantibodies can be indicative of autoimmune conditions. - Clinical history: A comprehensive history and sometimes imaging studies help determine the nature of the immune response. Natural methods to enhance antibody production include: - Nutrition: A well-balanced diet rich in vitamins A, C, D, E, and minerals like zinc can support immune function. Foods like fruits, vegetables, lean proteins, and whole grains can be beneficial. - Physical activity: Regular moderate exercise supports overall immune health. - Sleep: Adequate sleep is crucial for the immune system to function optimally. The body does possess mechanisms to regulate antibody production, responding dynamically to infections or vaccinations. Understanding these concepts can empower you to make informed decisions about your health. If you have specific conditions or symptoms related to your immune system, consider consulting a healthcare provider who can assist with tailored advice and testing based on your personal situation.
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Antigen

33 days ago
1 answers

I recently heard the term antigen, but I didn’t fully understand what it means. What exactly is an antigen, and how does it trigger an immune response? From what I read, an antigen is any substance that causes the immune system to produce antibodies, which help fight infections. But do antigens always come from viruses and bacteria, or can the body produce them naturally? I also learned that antigens are classified into different types, like self-antigens and foreign antigens. But how do vaccines use antigens to train the immune system, and why do some antigens cause allergic reactions? Another thing I wonder is whether antigens are used in medical tests. How do antigen tests detect diseases like COVID-19 or hepatitis, and are they always accurate? For those who have taken an antigen test, how reliable were the results, and did doctors use additional tests to confirm the diagnosis?


Dr. Evgeny Arsentev
31 days ago
An antigen is any substance that triggers the immune system to produce antibodies, which help defend the body against infections. Most commonly, antigens come from foreign invaders like viruses and bacteria. However, the body can also produce antigens, such as in autoimmune diseases where the immune system mistakenly targets its own tissues. Vaccines use antigens to "teach" the immune system how to recognize and respond to pathogens without causing illness. When the immune system encounters these antigens (from the vaccine), it prepares to fight off the actual infection in the future. Some antigens can cause allergic reactions when the immune system overreacts to harmless substances. Antigen tests, like those used for COVID-19 or hepatitis, detect the presence of specific antigens related to the virus or bacteria. These tests are useful for quick screening but may not always be 100% accurate. If an antigen test result is positive, doctors may confirm the diagnosis with a PCR test or other diagnostic methods for a more reliable result.
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